- Inhibit protein synthesis by binding to 50s ribosome near the acceptor (A) site
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- BM depression- most important cause of AA, agranulocytosis, thrombocytopenia, pancytopenia
- Hypersensitivity- Rashes, fever, atrophic glossitis, angioedema
- Irritative effects- Nausea, vomiting, diarrhea, pain on injection
- Superinfections- Similar to tetracycline
- Gray baby syndrome
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- Pyogenic meningitis- 2nd line drug for H. influenza and meningococcal meningitis, 1st line is – Cephalosporin
- Anaerobic infection- Bact. fragilis and others
- Intraocular infections
- Enteric fever- Most are now resistant used in past as 1st line drug
- 2nd line drug- Brucellosis, rickettsial, Whopping cough
- UTI
- Topical– Conjunctivitis, external ear infection
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