- Similar in MOA and spectrum to Erythromycin
- Inhibit protein synthesis by binding to 50s ribosome
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- Rashes, urticaria
- Major problem is diarrhea and pseudomembranous enterocolitis due to C. difficile superinfection which is potentially fatal
- The drug should be stopped and oral metronidazole (alternatively vancomycin) given to treat it.
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- Because of potential toxicity
- Use is restricted to anaerobic and mixed infection– esp. those involving Bact. fragilis- causing abdominal, pelvic and lung abscess
- It is first line of drug for these conditions and is generally combined with AG or Cephalosporin
- Topically for Acne Vulgaris
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